Medical Devices Can 3D cell Culture Add Benefits to Advance Research?

Can 3D cell Culture Add Benefits to Advance Research?

What are Cell Cultures?

Cell culture is the process of taking cells from any plant, animal or human then understanding and improving cell biology which  grows in an artificial environment or in a laboratory. This cell culture is used to research new drugs and diagnose many infections. In vitro and In vivo are techniques used for cell culturing and helps researchers discover and develop new drugs. 

Steps involved in drug discovery and development:

  • Discovery of drugs
  • Development of Pre-Clinic
  • Clinical Development
  • Regulatory approval

3-D Cell culture:

In traditional 2D cell culture cells are grown on a flat surface on a plate which provides unnatural growth of cell attachment. Monolayer on flat dishes is the main disadvantage of 2D cell culture. In 3D cell culture the cell culture grows and interacts with cells in 3d physical shape which provide advanced cell to cell interaction. 3D cell culture is an artificial environment in which biological cells grow or connect with their surrounding domain in 3-dimensions. 

3D cell culture is a culture environment that allows cells to grow and interact with surrounding extracellular frameworks in three dimensions. This is in contrast with traditional 2D cell cultures in which cells are grown in a flat monolayer on a plate. 3D cell cultures can be grown with or without a supporting scaffold. It expands types of different cells and tissues formulation which is not viable under two dimensional culture systems

3-D Cell culture Techniques:

Three-dimensional cell culture techniques are classified as Scaffold-based  3D Cell Cultures, Scaffold-free 3D Cell Cultures, Microfluidics-based 3D Cell Cultures and Magnetic & Bioprinted 3D Cell Cultures techniques. Researchers are required to select the most suitable and right technique for their cell-based investigation.

What makes  3D Cell Culture popular?

3d cell culture is mainly used in cancer research where cancer cells are mainly responsive to culture in vitro.

3d cell culture technique is grown in the natural environment because of this increasing tissue engineering and organ transplantation.

Scaffold based culture method provides an extracellular matrix on which cells are collected, multiplied and migrated.  In this cells are collected in the matrix and physical and chemical characteristics of scaffold material mold the properties of the cell.

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Cell culture techniques are mainly used to improve and develop the productivity in medical research. 3d cell culture is a powerful technique for discovery of drugs as compared to 2d cell culture technique because of cell to extracellular matrix (ECM) and cell to cell interaction. However 3d culture technique requires high throughput analysis and reproducibility to maintain validity and standardization of 3d culture technique.

Published Date : May-2021