Current Update for Diagnosis of influenza virus infection

What is Influenza?

Influenza is a chronic respiratory infection caused by a negative-stranded RNA in the Orthomyxoviridae family .  Humans are affected by three separate influenza viruses: influenza A, B, and C. Influenza is usually a mild illness that lasts 1–2 weeks in most people, but it can be severe in rare cases.

Some of the primary factors leading growth in the influenza diagnostics market include an ageing population, increased government anti-influenza programmes, growing prevalence of chronic diseases such as diabetes, heart disease, and blood disorders, and the advent of technologically advanced influenza diagnostic tests.

Diagnostic Tests for Influenza Infection

Rapid molecular assays 

Rapid molecular assays are a new type of molecular influenza diagnostic test with specificity and high sensitivity that has been a major development in the diagnosis of influenza in recent times.

Other Molecular Assays

Reverse Transcription-Polymerase Chain Reaction and other molecular tests may indicate the existence of viral RNA or nucleic acid influenza in respiratory samples obtained with a very high sensitivity and specificity. Some molecular tests are capable of detecting and discriminating between influenza A and B virus infections.

Rapid Influenza Diagnostic Tests

Rapid influenza diagnostic tests are virus isolation tests that can detect viral antigens in a few minutes with moderate sensitivity and high specificity.

 Serologic Testing

Serological influenza testing is not recommended for clinical decision-making. Since these are offered by some commercial laboratories, the results of serological tests for antibodies to influenza A or B viruses on a single serum specimen cannot be reliably interpreted.

Novel Influenza A Virus Infections

If human infection with novel influenza A virus of animal sources is detected, the local and state health services should be contacted to perform RT-PCR for seasonal influenza A viruses and novel influenza A viruses.

 commercial rapid influenza diagnostic tests

Commercial rapid influenza diagnostic tests are often used for the diagnosis of influenza due to its ability to detect influenza viruses with low to moderate sensitivity and high specificity within a few minutes.

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Conclusion: Diagnostic influenza involves a number of influenza tests that are used to detect influenza viruses in respiratory specimens. The most common are called diagnostic tests for rapid influenza. Rapid influenza diagnostic tests are performed to detect parts of the virus  that stimulate the immune response.

Published Date : May-2021

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