What is Membrane Chromatography?

Membrane chromatography is meant to be one of the robust separation tools that is mainly employed in almost all branches of science. It’s often considered as the only tool of separating components from complex combinations. A variety range of chromatographic procedures makes use of various sizes, affinities, charges and other properties. Uninterrupted chromatography has shown to be one of the most committed technology because it assures high-end utilization, purity and lower facility footprints.

What are the most recent developments in Membrane Chromatography?

Membrane chromatography uses a traditional flow that allows for high flow rates. Due to a limitation in binding site density, the typical highly permeable membrane structures that facilitate very short residence time operations have modest binding capability. Affinity and ion-exchange membranes with a combination of high dynamic antibody-loading capacities and a 10 second residence time have been established as a result of advances in membrane science aimed at overcoming this fundamental trade-off, paving the way for an intensified high-productivity, genuinely single-use purification platform.

This novel membrane chromatography design features a fast binding mechanism that can be used to achieve extremely short operating residence times (on the order of seconds) without sacrificing binding capability, resulting in extremely high productivity purification processes.

Membrane chromatography has the following advantages:

• High binding performance, even at high flow rates, due to direct access to the binding groups

• Speed – fast flow rates enable large quantities to be processed quickly.

• Versatility and scalability – a broad variety of capsule sizes accommodates a wide range of volumes and capacities.

• Convenient – the capsule shape removes the need to pack and unpack. There are no washing or cross-contamination problems when used in a single-use manufacturing process.

• Lower operational costs – compared to traditional columns that require packaging, membrane capsules have lower operating and capital costs.

• Lower buffer use – a limited system footprint necessitates considerably less buffer.

• Affinity membranes with potential for other applications allow for process intensification.

• Fully single-use processes allow for more versatile and low-cost facilities, as well as improved facility utilisation.

Final Thoughts:

Novel membrane devices with high binding capabilities and enhanced mass transfer properties have resulted from advances in membrane chemistry. Because of its disposable design, low buffer use, and lower equipment costs, membrane chromatography will dramatically reduce downstream bioprocessing costs. The membrane chromatography market is expected to develop at a rapid pace over the forecast period, owing to factors such as rising demand for biopharmaceuticals and the significant advantages of membrane chromatography over traditional chromatography technology.

Membrane Chromatography Market: 15.6% CAGR

Projected Revenue: 545.2 million from 2021 to 2027

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Published Date : March-2021